The science
Your biology,
rendered as a formula.
650,000+ genotypes per sample, filtered to our panel of 73 markers with the strongest published links to nutrient metabolism and everyday wellness traits. The 48 that change what your body does with a nutrient are evaluated against a proprietary rules engine, then blended into one bottle.
Primer
What is a SNP?
Single nucleotide polymorphisms, SNPs, pronounced “snips”, are single-letter variations in your DNA. They’re the reason two people can take the same supplement and experience entirely different results.
Two copies of a common SNP in your MTHFR gene leave the enzyme that activates folate with about a third of its usual activity in laboratory measurements. A SNP in VDR changes the vitamin D receptor itself, and one version was less active in cell studies. A SNP in IL1B is associated with differences in how much IL-1β, one of the signals in your body’s inflammatory response, you make.
Millions of SNPs exist. We’ve curated the 48 with the clearest evidence linking genotype to nutrient need, and built a formula engine around them.
How many of these markers can be read from any one sample depends on the sample and on the lab's genotyping array: the array our lab uses from November 2026 does not carry two of the 48 formula markers, and your dashboard shows how many were read from yours.
How the field got here
None of this is new. It’s just newly affordable.
Trait didn’t invent nutrigenomics. We stand on seventy years of published science. Every milestone below is a real, documented event, click any source and verify it yourself.
1953
The double helix
Watson and Crick describe the structure of DNA in Nature — the physical basis for how genetic information is stored and copied.
Nature 171:737 (1953) ↗1990
The Human Genome Project begins
An international public effort launches to read all ~3 billion letters of human DNA — the reference every modern genetic test is compared against.
genome.gov — HGP ↗1995
MTHFR is linked to folate metabolism
Frosst and colleagues identify the common C677T variant in MTHFR that reduces folate-processing enzyme activity — one of the most-studied nutrient-related variants, and a tier-1 marker in our panel.
Nat Genet 10:111, PMID 7647779 ↗2003
The genome is finished
The Human Genome Project completes a reference sequence of human DNA, on the 50th anniversary of the double helix. It is the reference that every later genetic test, including ours, compares a sample against.
genome.gov — 2003 completion ↗2005
A map of human variation (HapMap)
The International HapMap Project catalogs more than a million common SNPs that differ between people, the kind of variation nutrigenomics research studies.
Nature 437:1299 (2005) ↗2008
GINA becomes law
The Genetic Information Nondiscrimination Act makes it illegal for health insurers and employers to use your genetic information against you. It does not cover life, disability or long-term care insurance.
Public Law 110-233 ↗2014
Early evidence people act on their genes
In a 138-person randomized trial, people told they carry a risk version of the ACE gene, and advised to limit salt, cut their sodium intake over 12 months more than people given general advice. Intakes of the other nutrients studied did not differ.
PLoS One 9:e112665, Nielsen & El-Sohemy ↗2018
Personalized nutrition: promise, and open questions
A BMJ review finds that in the largest trial so far, personalised advice changed diets more than one-size-fits-all advice, with no evidence of extra benefit from adding genetic information, and that more work is needed before personalised nutrition can deliver.
BMJ 361:k2173 (2018) ↗
Why 3 months
Your biology doesn’t move on a monthly billing cycle.
The things we’re changing take weeks to months to move, which is why a membership runs in three-month terms. Three examples, each published, each verifiable below.
Vitamin D
8–12 weeks to plateau25(OH)D — the form measured in blood — has a half-life of roughly two to three weeks, and a level only settles after several half-lives. In this randomized trial of three vitamin D dosing schedules, blood levels reached a plateau after eight weeks. It is why trials retest at 8 to 12 weeks, not at 30 days.
Nutrients (2015), dose-response of three vitamin D schemes ↗Omega-3 Index
12 weeks or longer to moveThe Omega-3 Index measures EPA and DHA in your red blood cell membranes, so those fatty acids have to be built into new cells. Across the 58 studies in this review, raising it to the recommended level took daily EPA and DHA for 12 weeks or longer. (Omega-3 is not in the base formula; it is an optional add-on, priced separately.)
Frontiers in Nutrition (2023), scoping review ↗Red blood cells
~120 days to turn overA red blood cell lives about four months. Any marker carried in that cell population cannot fully reflect a change in your nutrition until most of those cells have been replaced. One month of anything is a fraction of one cell cycle.
J Biol Chem (1946), the life span of the human red blood cell ↗There is also the plain economics
A month at a time would cost you more, for the same formula.
Your formula is made for you alone, and a custom production run costs roughly the same whether it makes 30 days of supply or 90. Billing monthly would mean charging about 2.3× more per month for the identical bottle, nearer $370 than $159. We would rather hold the price and ask for the window the science needs anyway.
In the field’s own words
“We have caught the first glimpse of our own instruction book, previously known only to God.”
Dr. Francis Collins — geneticist who led the Human Genome Project and later directed the U.S. National Institutes of Health, announcing the first draft of the human genome, June 2000.
Two decades later, that instruction book is readable for the price of a nice dinner. The science was always there. What changed is that a person can now afford to have their own copy read, and to do something useful with it.
Quotation attributed to Dr. Collins is a matter of public record. Dr. Collins is not affiliated with and does not endorse Trait.
The pipeline
From genotype to nutrient action.
Eight of the eleven biological categories we evaluate, and the nutrient actions they point to. The weights reflect approximate rule density, methylation alone involves six genes. Some of the actions shown are blended into your bottle and some are suggestions: an optional add-on, or a supplement you would take separately. Your own dashboard says which is which for every ingredient.
The panel composition
11 categories.
One coherent formula.
Each formula marker belongs to one of eleven biological systems. The rules engine weights them against each other, for example, a methylation variant that would normally push more methylfolate is capped if you also carry a variant that speeds up sulfur metabolism.
The output is a formula that’s internally consistent, not a pile of independent recommendations.
Hover a sector to explore, figures illustrative of the Trait panel composition.
End to end
From sample to bottle.
DNA Sample
650,000+ genotypes
Curated Panel
73-marker panel
Rules Engine
Genotype → nutrients
Conflict Resolution
Interactions checked
Your Formula
Custom-blended
DNA Sample
650,000+ genotypes
Curated Panel
73-marker panel
Rules Engine
Genotype → nutrients
Conflict Resolution
Interactions checked
Your Formula
Custom-blended
Worked example
Four real variants. Four real adjustments.
Scroll through four SNPs from the panel. Each card shows the variant, the biological readout, and the exact nutrient action — while the formula panel on the right assembles in real time.
Detected variant: C677T, two copies
Readout — Reduced folate activation
Action — Raise active methylfolate (5-MTHF) above the base dose
Detected variant: FokI, two copies
Readout — Associated with a less active vitamin D receptor
Action — Raise cholecalciferol above the base dose
Detected variant: IL-1β promoter variant, two copies
Readout — Associated with differences in IL-1β, an inflammatory signal
Action — Add quercetin (non-base ingredient)
Detected variant: Val16Ala, two copies
Readout — Sits in the signal that carries an antioxidant enzyme into mitochondria
Action — Add mitochondrial antioxidant support
Your formula, building now
One bottle,
shaped by your DNA.
5-MTHF (active folate)
via MTHFR
Vitamin D3
via VDR
Quercetin
via IL1B
NAC + Alpha-Lipoic Acid
via SOD2
Illustrative example, using real doses from our rules engine, and every variant shown is on the array our lab uses from November 2026. Your own formula is built from our 48-marker formula panel; how many of those markers can be read depends on your sample and the lab’s array, and your dashboard shows the count. Most of the work is dose and form changes across the foundational base, plus a small number of added ingredients, capped at five so the bottle stays focused. A few ingredients our engine may point to, such as omega-3, CoQ10, curcumin and berberine, are offered as separately priced add-ons rather than blended in by default, and your dashboard says which is which.
Straight answers
What this is, and what it isn’t.
What it is
- A way to match well-evidenced nutrients to the specific variants in your DNA, instead of guessing.
- Built on published, peer-reviewed research — every marker traces back to a citation.
- Read once. Your DNA doesn’t change, so the analysis stays valid for life.
- A wellness and nutrition tool, designed to support how your body already works.
What it isn’t
- Not a diagnosis. We don’t test for diseases, and we don’t predict them.
- Not a clinical genetic test, carrier screen, or ancestry report.
- Not a replacement for your doctor. Talk to a clinician before changing anything, especially on medication.
- Not a promise of a specific outcome. Biology varies, and we won’t pretend otherwise.
Verified
Lab-grade. Standards-bound.
CLIA
Certified Lab
#26D2106631
CAP
Accredited
Pathology standards
NSF
cGMP Certified
Manufacturing
Genotyping by Dynamic DNA Labs (CLIA #26D2106631, CAP-accredited, Springfield, MO). Manufacturing by Personalized Nutrients at an NSF cGMP-certified facility in Sisters, Oregon.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ready to see your own?
Order your DNA kit: $149, one time, no subscription required.
Begin your formula